In the realm of fusion power, where the sun's secrets are sought to fuel our future, a pivotal transition is underway. The focus is shifting from experimental facilities to the development of commercially viable fusion power plants. This shift demands a profound rethinking of instrumentation and control (I&C) systems, which are the linchpins of these advanced reactors. The challenge lies not just in engineering but in crafting systems that can withstand the extreme conditions of a fusion power plant, where the fusion process that powers the sun must be contained and harnessed. The transition from experimental setups to power plants is akin to designing a plane in a wind tunnel and then building and flying the actual aircraft. It's a leap of faith, requiring a deep understanding of the plasma's behavior and the ability to repeat and optimize the fusion process reliably. The I&C systems in a fusion power plant serve a fundamentally different role compared to research facilities. In a power plant, diagnostics are not just for understanding the plasma but for controlling and operating the system efficiently. This necessitates cost minimization, leading to the scaling down of instrumentation to the bare essentials. The instruments that do remain must endure neutron and gamma fluxes, which can accelerate material degradation and increase signal noise. This is a far cry from the complex, customized diagnostic systems found in research facilities. The basic science for developing these robust I&C systems is well understood, but the practical challenges are immense. Increased shielding can protect instruments from irradiation, but it can also hinder certain measurements. Moving instruments further away from the machine can reduce radiation exposure but may decrease signal strength due to longer cables. The question isn't whether instruments can operate in this harsh environment but for how long. For instance, cheap digital cameras used in some facilities don't last long and must be replaced regularly. The study of fusion power is at a turning point, with researchers actively working to bridge the gap between experimental and commercial applications. This includes exploring target concepts, innovative instruments, digital twins, and more. New technologies, such as superconducting magnetics and high-sample-rate diagnostics, are opening new possibilities. However, the path to commercial viability is not without hurdles. AI/machine learning, while effective for control applications, often falls short of regulatory reliability standards. To address this, control systems are being designed with a layered approach, where the inner layers are 'smart' and the outer layers are 'dumb', with the outermost layer being the nuclear safety control system. The development of I&C for commercial fusion systems is not an afterthought but a critical component. Diagnostics affect every aspect of operation, from plasma startup to shutdown, and play a pivotal role in machine protection. The technology developed for research reactors serves as a testing ground, laying the foundation for commercial power reactors. In the grand scheme of things, the transition from experimental to commercial fusion power is a testament to human ingenuity and our relentless pursuit of clean, abundant energy. It's a journey that requires sustained development, testing, and resources, but the potential rewards are immense. As we navigate this transition, we must embrace the challenges and opportunities that lie ahead, for the future of fusion power is bright, and the possibilities are endless.